Activation of bovine factor VII by hageman factor fragments
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منابع مشابه
Activation of bovine factor VII by hageman factor fragments.
During the early events of coagulation of human blood by the intrinsic pathway, factor XII is activated to a form which can activate factor XI, and is proteolytically fragmented to smaller species (30,000 daltons and 70,000 daltons) which have lost most of the ability to activate factor XI but which can activate prekallikrein rapidly. The effect of these fragments on factor VII was studied. It ...
متن کاملThe activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments.
Activation of plasminogen through surface-mediated reactions is well recognized. In the presence of kaolin, purified Hageman factor (Factor XII) changed plasminogen to plasmin, as assayed upon a synthetic amide substrate and by fibrinolysis. Kinetic studies suggested an enzymatic action of Hageman factor upon its substrate, plasminogen. Hageman factor fragments, at a protein concentration equiv...
متن کامل798 Hageman Factor Activation
Bacterial lipopolysaccharides (LPS) I or endotoxins elicit a variety of host responses, the combination of which result in the deposition of fibrin in capillaries and disseminated intravascular coagulation (DIC). These various host responses to endotoxins have recently been summarized (1) and include: (a) aggregation of platelets and release of platelet factor 3; (b) activation of Hageman facto...
متن کاملStudies on the inhibition of ellagic acid-activated Hageman factor (factor XII) and Hageman factor fragments.
Hageman factor (HF, factor XII) that has been exposed to Sephadex-ellagic acid gels is a single-chain species (HFea) with amidolytic properties for the synthetic substrate H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide. Earlier we reported that amidolysis was suppressed by incubation of HFea with specific antiserum. The present study provides additional evidence that the amidolytic prop...
متن کاملActivation of Hageman factor by collagen.
Purified acid-soluble and insoluble human collagen accelerated the clotting of plateletpoor plasma in silicone-treated tubes. The clot-promoting effect did not appear to be due to thromboplastic activity since the collagen preparations did not activate factor X in the presence of factor VII and calcium. Instead, collagen appeared to accelerate clotting by activating Hageman factor (factor XII) ...
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ژورنال
عنوان ژورنال: Blood
سال: 1977
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v50.4.611.611